RNA Details
Disease Name
ventricular dysfunction
Tissue
heart
RNA Symbol
mir-23b
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
dual-luciferase reporter assay; qPCR
Target
GIF1;PTEN
Pathway
PI3K-AKT SIGNALING PATHWAY;TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Inhibition of microRNA-23b prevents polymicrobial sepsis-induced cardiac dysfunction by modulating TGIF1 and PTEN
Year
2018
Function
miR-23b is a critical contributor to the activation of cardiac fibrosis to mediate the development of myocardial dysfunction in late sepsis.